Two clinical trials were conducted, a randomized placebo-controlled trial and a positive-controlled randomized trial. All the wounds were bleeding through incision of abdominal wall in abdominal surgery. The main therapeutic indexes were blood loss, hemostasis time and blood loss per unit area. Randomized placebo in clinical trials in 180 cases of human: proportion of random equivalent points to placebo, 2 u and 3 u three groups, the preoperative 15-20 minutes a single intravenous dosing, results suggest this two doses in the bleeding, bleeding time and blood loss per unit area index were superior to placebo, but no concentration-response relationship between two groups. In the positive control trial, there were 324 patients in the experimental group and 108 patients in the control group, and a single dose of 2U was given in the experimental group 15-20 minutes before surgery by single intravenous injection. No adverse reactions were observed in the above tests.