In recent years, the biochemical hemostatic drugs mainly composed of snake venom enzyme have been the most widely used in clinic and become the mainstream of therapeutic drugs development. Hemostatic agents, also known as procoagulant drugs, are mostly drugs that play a role in the process of blood coagulation, including accelerating blood coagulation or reducing capillary permeability to stop bleeding. They are the main and indispensable therapeutic drugs for the clinical treatment of hemorrhagic diseases or bleeding state.