Analgesia
Snake venom hemagglutinin injections previously sold in the market mainly include snake venom hemagglutinin injection (trade name: Sulejuan), snake venom hemagglutinin injection (trade name: Bangting), agkistrodon halys hemagglutinin injection (trade name: However, systematic evaluation showed that there was no significant difference in hemostatic efficiency and the incidence of adverse reactions among the three snakes.Snake venom class blood clotting enzyme is a biological preparation, from the chemical structure, belongs to the heterologous protein, and mast cells in vivo or basophilic cell surface molecules, a series of reactions in the cell, vascular active substances, such as histamine release, slow reaction substances, type Ⅰ allergy effects on the body, may also be associated with the enzyme contains impurities. At the same time, both surgical trauma and postoperative pain can lead to acute phase response (APR), such as increased body temperature, increased blood glucose, increased catabolism, negative nitrogen balance and increased plasma acute phase protein (APP) concentration. At this time to give allogenic protein, the body is prone to allergic, or even severe allergic reaction. Zhao Shanshan et al. analyzed literature on case reports of adverse reactions of snake venom hemagglutinase injection, and found that 57 of 69 cases of adverse reactions occurred within 1 hour after injection, and 35 of them occurred within 1 ~ 5 minutes after injection. Acute rapid-onset allergic reaction, if found in time or improper handling, the rapid development of the disease and dangerous, will cause adverse consequences to patients.Therefore, indications should be strictly controlled in clinical use, and the patient's medical history, medication history, allergy history and family history should be carefully inquired before the first use. Prepare medicines and articles needed for emergency treatment before use. The injection speed should be slow, and patients' vital signs and other changes should be closely observed at the beginning of the medication. After careful observation for several minutes, patients can leave to ensure that there are no adverse reactions.Just click here to learn more about our products.